Polycomb Group Protein Bodybuilding: Working Out the Routines
نویسندگان
چکیده
منابع مشابه
Polycomb group protein complexes exchange rapidly in living Drosophila.
Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group (PcG) proteins in whole living Drosophila organisms (embryos) and tissues (wing imaginal discs and salivary glands). PcG genes are essential genes in higher eukaryotes responsible for the maintenance of the spatially distinct repression of developmentally important regulat...
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Tyrosine kinase inhibitors (TKI) have revolutionized chronic myelogenous leukemia (CML) management. Disease eradication, however, is hampered by innate resistance of leukemia-initiating cells (LIC) to TKI-induced killing, which also provides the basis for subsequent emergence of TKI-resistant mutants. We report that EZH2, the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), is overexp...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2013
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2013.09.012